Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (E)-5-Methyl-2-(4-methoxystyryl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-Methyl-2-nitroaniline | HCID 6978 | — |
| 반응물 | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| 반응물 | trans-4-Methoxycinnamoyl chloride | HCID 10976422 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (E)-5-Methyl-2-(4-methoxystyryl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride | HCID 18360812 | — |
반응 단계
Free base of the titled compound was prepared from 4-methyl-2-nitroaniline and (E)-4-methoxycinnamoyl chloride according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base was dissolved with a 10% methanol solution of hydrogen chloride (5 ml). Concentration and recrystallization from ethyl acetate/ethanol yielded the titled compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06310079B1 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-1b3ce5fe73c64cc1b630a5b48c7e592d |
| 출처 메모 | uspto-grants-2001_10 |