Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Oxalic Acid → (E)-1-(2-Pyridyl)-2-[2-(3-pyridyl)ethenyl]-1H-benzimidazole oxalate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Oxalic Acid | HCID 971 | — |
| 반응물 | 3-Pyridinecarboxaldehyde | HCID 10371 | — |
| 반응물 | 2-Methyl-1-(pyridin-2-yl)-1H-benzimidazole | HCID 22736643 | — |
| 반응물 | (E)-1-(2-Pyridyl)-2-[2-(2-pyridyl)ethenyl]-1H-benzimidazole dihydrochloride | HCID 22736657 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (E)-1-(2-Pyridyl)-2-[2-(3-pyridyl)ethenyl]-1H-benzimidazole oxalate | HCID 22736735 | — |
반응 단계
Free base of the titled compound was prepared from 2-methyl-1-(2-pyridyl)-1H-benzimidazole and pyridine-3-carboxaldehyde according to the preparation of (E)-1-(2-pyridyl)-2-[2-(2-pyridyl)ethenyl]-1H-benzimidazole dihydrochloride (Example 44). The free base and oxalic acid were dissolved into MeOH. Concentration and recrystallization from ethyl MeOH/EtOH yielded the titled compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06310079B1 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-0fc7c89e3ade461b9d7d2308e376abb1 |
| 출처 메모 | uspto-grants-2001_10 |