Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 38261생성일: 2026년 10월 23일
Triethylamine → [1-[(Phenylmethyl)sulfonyl]-3-pyrrolidinyl]-carbamic acid, 1,1-dimethylethyl ester
https://huagongshe.com/ko/reaction/38261
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Phenylmethanesulfonyl chloride | HCID 74740 | — |
| 반응물 | tert-butyl N-(pyrrolidin-3-yl)carbamate | HCID 2757234 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | [1-[(Phenylmethyl)sulfonyl]-3-pyrrolidinyl]-carbamic acid, 1,1-dimethylethyl ester | HCID 91332323 | 65.9% |
반응 단계
To a solution/suspension of 3-pyrrolidinyl-carbamic acid, 1,1-dimethylethyl ester (0.5 g) and triethylamine (0.38 ml) in dichloromethane (30 ml) at 0° C. was added benzenemethanesulfonyl chloride (0.51 g). The mixture was stirred at 0° C. for 30 minutes then stirred at room temperature for 2 days. The reaction was diluted with dichloromethane (20 ml) washed with water, saturated aq. NaHCO3(aq), dried (MgSO4) and concentrated in vacuo to give the sub-title compound (0.6 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08524715B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-dbe3b2d374234cb39ea5c3d57766ebce |
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| 출처 메모 | uspto-grants-2013_09 |
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