Diketene → HCID 23004067, 화합물

HRID 382682노트

반응식

HRID 382682 반응식
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[NH2:7][CH2:8][CH2:9][CH2:10][N:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][C:15]([O:23][CH3:24])=[C:16]([O:21][CH3:22])[CH:17]=2)[CH2:12]1>C1COCC1>[CH3:22][O:21][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][C:15]=1[O:23][CH3:24])[CH2:12][N:11]([CH2:10][CH2:9][CH2:8][NH:7][C:4](=[O:5])[CH2:3][C:2]([CH3:1])=[O:6])[CH2:20][CH2:19]2

참가 물질

4

반응물 2

HCID 12661DiketeneHCID 230040563,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinepropanamine

생성물 1

HCID 23004067HCID 23004067, 화합물수율 100%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Diketene (1.41 mL, 18.3 mmol, 1.50 equiv) was added at 0° C. to a stirred solution of 2-(3-aminopropyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline (3.05 g, 12.2 mmol, 1.00 equiv) in anhydrous THF (30 mL) under argon, and stirring was continued at room temperature for 1.5 hours. The mixture was concentrated and the residual oil washed with hexane (2×100 mL) to give 4.07 g (100%) of brown oil, which was characterized spectroscopically and used for the next reaction without purification.

후처리

  1. concentrationThe mixture was concentrated
  2. washthe residual oil washed with hexane (2×100 mL)

출처 및 근거

ORD 기록
ord-445cc6f43f1141fc84526c982e2bd73f
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06310076B1

반응 노트

불러오는 중…