4-Chlorophenylacetyl chloride → [4-Chloro-2-[[(3S)-4-[(4-chlorophenyl)acetyl]-3-methyl-1-piperazinyl]methyl]phenoxy]acetic Acid

HRID 38270

반응식

HRID 38270 반응식
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[C:4]([CH2:13][N:14]2[CH2:19][CH2:18][N:17](S(CC3C=CC=CC=3)(=O)=O)[C@@H:16]([CH3:30])[CH2:15]2)[CH:3]=1.[Cl:31][C:32]1[CH:37]=[CH:36][C:35]([CH2:38][C:39](Cl)=[O:40])=[CH:34][CH:33]=1>>[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[C:4]([CH2:13][N:14]2[CH2:19][CH2:18][N:17]([C:39](=[O:40])[CH2:38][C:35]3[CH:36]=[CH:37][C:32]([Cl:31])=[CH:33][CH:34]=3)[C@@H:16]([CH3:30])[CH2:15]2)[CH:3]=1

참가 물질

3

반응물 2

HCID 906924-Chlorophenylacetyl chlorideHCID 11698153[4-Chloro-2-[[(3S)-3-methyl-4-[(phenylmethyl)sulfonyl]-1-piperazinyl]methyl]phenoxy]acetic Acid

생성물 1

HCID 51357124[4-Chloro-2-[[(3S)-4-[(4-chlorophenyl)acetyl]-3-methyl-1-piperazinyl]methyl]phenoxy]acetic Acid

실험 절차

Prepared by the method of example 62 part (e) using the product from example 62 part (d) and 4-chlorobenzeneacetyl chloride to give the title compound.

출처 및 근거

ORD 기록
ord-5c05e2e884e441e7835286caf71f8ade
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524715B2

연결된 노트

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