Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenylacetic Acid → 2,5-Dimethyl-1-(phenylacetyl)-piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenylacetic Acid | HCID 999 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2,5-Dimethylpiperazine, trans- | HCID 220672 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2,5-Dimethyl-1-(phenylacetyl)-piperazine | HCID 64979394 | 178.8% |
반응 단계
Diisopropylethylamine (0.38 ml) was added to a solution of trans-2,5-dimethyl-piperazine (1.50 g), phenyl acetic acid (0.59 g) and HATU (1.55 g) in DMF (10 ml). The reaction mixture was stirred overnight at ambient temperature. The solution was diluted with water, then extracted with ethyl acetate. The organic extracts were dried (MgSO4) then concentrated in vacuo to give the sub-title compound (1.8 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524715B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-715e1f13ccc9473e8841e52835088166 |
| 출처 메모 | uspto-grants-2013_09 |