4-(2-Chloro-ethanesulfonyl)-phenol → (3S,4S)-4-[2-(4-benzyl-3-hydroxy-piperidin-1-yl)-ethanesulfonyl]-phenol

HRID 382782

반응식

HRID 382782 반응식
Cl[CH2:2][CH2:3][S:4]([C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)(=[O:6])=[O:5].[CH2:14]([C@H:21]1[CH2:26][CH2:25][NH:24][CH2:23][C@H:22]1[OH:27])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH2:14]([C@H:21]1[CH2:26][CH2:25][N:24]([CH2:2][CH2:3][S:4]([C:7]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=2)(=[O:6])=[O:5])[CH2:23][C@H:22]1[OH:27])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

참가 물질

3

반응물 2

HCID 98132494-(2-Chloro-ethanesulfonyl)-phenolHCID 9899064(3S,4S)-4-benzylpiperidin-3-ol

생성물 1

HCID 9885963(3S,4S)-4-[2-(4-benzyl-3-hydroxy-piperidin-1-yl)-ethanesulfonyl]-phenol수율 66%

실험 절차

The title compound was prepared from 4-(2-chloro-ethanesulfonyl)-phenol and (3S,4S)-4-benzyl-piperidine-3-ol in 66% yield as a white solid.

출처 및 근거

ORD 기록
ord-c91a9fc152084e0d997e615e36a8c9c6
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06310213B1

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