Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chlorobenzylamine → N-[(4-Chlorophenyl)methyl]-8-hydroxy-2-methyl-7-quinolinecarboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chlorobenzylamine | HCID 66036 | — |
| 반응물 | 8-Hydroxy-2-methylquinoline-7-carboxylic acid | HCID 469823 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-[(4-Chlorophenyl)methyl]-8-hydroxy-2-methyl-7-quinolinecarboxamide | HCID 18372652 | 68.7% |
반응 단계
To a solution of 8-hydroxy-2-methylquinoline-7-carboxylic acid (0.305 g) of Preparation 5 and 4-chlorobenzylamine (0.219 g) in 20 mL DMF is added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.305 g) and 1-hydroxybenzotriazole monohydrate (0.217 g). The mixture is stirred overnight. The solution is then poured into 30 mL ice-water. The resulting solid is collected and dried to yield 0.337 g of the title product as an off-white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06310211B1 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-93766d433a7b49d5950392734e125457 |
| 출처 메모 | uspto-grants-2001_10 |