Triethylamine → HCID 614880, 화합물

HRID 382885노트

반응식

HRID 382885 반응식
Cl[C:2]1[C:11]2[C:6](=[C:7]([O:12][CH3:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:14]([F:17])([F:16])[F:15])[CH:3]=1.CCN(CC)CC>CCO.[Pd]>[CH3:13][O:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]=[C:4]([C:14]([F:17])([F:15])[F:16])[CH:3]=[CH:2]2

참가 물질

5

반응물 2

HCID 8471TriethylamineHCID 6215244-Chloro-8-methoxy-2-(trifluoromethyl)quinoline

생성물 1

HCID 614880HCID 614880, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of 4-chloro-8-methoxy-2-trifluoromethylquinoline (0.57 g) in 5 mL absolute EtOH is added 10% Pd/C (125 mg) and NEt3 (0.3 mL). The reaction is hydrogenated under atmospheric pressure for 0.75 h. The reaction is then filtered. over Celite and the filtrate is evaporated. The residue is taken up in Et2O and the triethylamine hydrochloride salt is filtered. The desired product is obtained as a light yellow solid by evaporation of the Et2O filtrate (0.38 g).

후처리

  1. filtrationThe reaction is then filtered
  2. customover Celite and the filtrate is evaporated
  3. filtrationthe triethylamine hydrochloride salt is filtered

출처 및 근거

ORD 기록
ord-b4a6e93e5ac148e0a7295bffcc22efc5
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06310211B1

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