Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → alpha-Amino-1,3-benzodioxole-5-acetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Piperonal | HCID 8438 | — |
| 반응물 | Potassium Cyanide | HCID 9032 | — |
| 반응물 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | alpha-Amino-1,3-benzodioxole-5-acetonitrile | HCID 4405684 | — |
반응 단계
Piperonal (6.00 g) is dissolved in THF (25 mL) and aq. NH3 (58%, 4.2 mL), NH4Cl (3.3 g) and KCN (3.9 g) are added. The mixture is stirred efficiently for 24 h. MgSO4 is added and the mixture stirred for 30 min., filtered and washed with THF The filtrate is evaporated under reduced pressure and the residue purified by FC (Et2O/petrol ether 1:2,→2:1,→Et2O). Aminonitrile W-99 is obtained as a brown, unstable oil (2.87 g). The hydrochloride salt is precipitated from sat. HCl/Et2O for analytical purposes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06310211B1 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-ed0297be245e41a784d8d777021bd689 |
| 출처 메모 | uspto-grants-2001_10 |