Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trityl chloride → (S)-4-N-Trityl-2-methyl-piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trityl chloride | HCID 6456 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Methylpiperazine | HCID 66057 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (S)-4-N-Trityl-2-methyl-piperazine | HCID 7171814 | — |
반응 단계
(S)+-2-methylpiperazine (10 g) was dissolved in acetonitrile (140 ml) and cooled to 5-10° C. whereupon triethylamine (35 ml) was added, followed by drop wise addition of a solution of trityl chloride 27.9 (g) in DCM (80 ml). The reaction was stirred for 1 h at room temperature. The resulting slurry was cooled to approximately 0° C. then filtered. The filtrate was evaporated in vacuo and the residue was purified by chromatography (silica, 1-4% MeOH/DCM as eluent) to give the sub-title compound (29 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524715B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-3a98d504e8e4451b97bff5363160ad09 |
| 출처 메모 | uspto-grants-2013_09 |