Bromine → Ethyl 3-bromo-4-oxobutanoate

HRID 383111

반응식

HRID 383111 반응식
[CH2:1]([O:3][C:4](=[O:9])[CH2:5][CH2:6][CH:7]=[O:8])[CH3:2].[Br:10]Br>C(OCC)C>[CH2:1]([O:3][C:4](=[O:9])[CH2:5][CH:6]([Br:10])[CH:7]=[O:8])[CH3:2]

참가 물질

4

반응물 2

HCID 24408BromineHCID 82395Ethyl 4-oxobutanoate

생성물 1

HCID 15576269Ethyl 3-bromo-4-oxobutanoate수율 66.5%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a 0-5° C. mechanically-stirred solution in diethyl ether (100 mL) of succinaldehydic acid ethyl ester (10.0 g, 77 mmol) was added bromine (3.9 g, 151 mmol) over 2.5 hours. The reaction mixture was stirred for an additional 1.25 hours and the ether was distilled at atmospheric pressure. The remaining yellow oil was distilled (6.0-6.5 mm Hg, bp 95-101° C.) to give 3-bromosuccinaldehydic acid ethyl ester (10.7 g, 66%).

후처리

  1. distillationthe ether was distilled at atmospheric pressure
  2. distillationThe remaining yellow oil was distilled (6.0-6.5 mm Hg, bp 95-101° C.)

출처 및 근거

ORD 기록
ord-e27d267f52fb48c582371c116a9045d5
출처 데이터셋
uspto-grants-2001_10
특허 번호
US06310095B1

연결된 노트

불러오는 중…