HCID 12545264, 화합물 → N~1~-([1,1'-Biphenyl]-2-yl)benzene-1,2-diamine

HRID 383214노트

반응식

HRID 383214 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11]1[C:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:13][CH:14]=[CH:15][CH:16]=1)([O-])=O.[H][H]>[Pd].C(O)C>[C:12]1([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[NH:10][C:5]1[C:4]([NH2:1])=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

5

반응물 2

HCID 12545264HCID 12545264, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 13989156N~1~-([1,1'-Biphenyl]-2-yl)benzene-1,2-diamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

N-(2-nitrophenyl)biphenyl-2-amine (19.69 g, 67.8 mmol), 10% palladium on carbon (0.29 g, 0.27 mmol), and 150 mL of ethanol was added to a Parr hydrogenator bottle. The mixture was hydrogenated on a Parr hydrogenator until no more hydrogen was taken up by the solution. The solution was filtered through Celite to remove the catalyst, Celite was washed with dichloromethane, the filtrate was evaporated to yield a brown oil, 14.8 g (84%). The product was used for the next step without further purification.

후처리

  1. filtrationThe solution was filtered through Celite
  2. customto remove the catalyst, Celite
  3. washwas washed with dichloromethane
  4. customthe filtrate was evaporated
  5. customto yield a brown oil, 14.8 g (84%)
  6. customThe product was used for the next step without further purification

출처 및 근거

ORD 기록
ord-8fa2ac664396495a8847c2a25ca89096
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367223B2

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