Bromine → 3-Bromo-6-chloroimidazo[1,2-a]pyridine
반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.[Br:11]Br>C(O)(=O)C>[Br:11][C:8]1[N:6]2[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]2=[N:10][CH:9]=1참가 물질
4
실험 절차
To 6-chloro-imidazo[1,2-a]pyridine (1 eq, 253 mmol, 39 g) in acetic acid (500 ml) under inert atmosphere, is added dropwise bromine (1 eq, 253 mmol, 13 ml). After 1 hour stirring at room temperature, the reaction mixture is filtered and to give a beige solid (64 g) 3-Bromo-6-chloro-imidazo[1,2-a]pyridine hydrobromide; [M+H]+232 (234)
후처리
- filtrationthe reaction mixture is filtered
출처 및 근거
- ORD 기록
- ord-03eec8a302ca479eb68e62273cc9109a
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08367662B2
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