Bromine → 3,6-Dibromoimidazo[1,2-a]pyridine

HRID 383311노트

반응식

HRID 383311 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.[Br:11]Br>C(O)(=O)C>[Br:11][C:8]1[N:6]2[CH:7]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]2=[N:10][CH:9]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 27955476-Bromoimidazo[1,2-a]pyridine

생성물 1

HCID 467390843,6-Dibromoimidazo[1,2-a]pyridine

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To 6-bromo-imidazo[1,2-a]pyridine (1 eq, 96 mmol, 19 g) in acetic acid (200 ml) under an inert atmosphere of argon is added dropwise bromine (1 eq, 96 mmol, 4.9 ml). After stirring at room temperature for 1 hour, the reaction mixture is filtered to afford the title compound as a beige solid; [M+H]+=275/277/278

후처리

  1. filtrationthe reaction mixture is filtered

출처 및 근거

ORD 기록
ord-791616322fe3435197f43cfde7ffb08e
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367662B2

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