Bromine → 3-Bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine

HRID 383313노트

반응식

HRID 383313 반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH:9]=[CH:10][N:11]=2)[CH:8]=1.[Br:14]Br>C(O)(=O)C>[Br:14][C:9]1[N:7]2[CH:8]=[C:3]([C:2]([F:1])([F:12])[F:13])[CH:4]=[CH:5][C:6]2=[N:11][CH:10]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 401480116-(Trifluoromethyl)imidazo[1,2-a]pyridine

생성물 1

HCID 455882283-Bromo-6-(trifluoromethyl)imidazo[1,2-a]pyridine

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To 6-trifluoromethyl-imidazo[1,2-a]pyridine (1 eq, 6.2 mmol, 1.1 g) in acetic acid (15 ml) under an inert atmosphere of argon is added dropwise bromine (1 eq, 6.2 mmol, 0.313 ml). After stirring at room temperature for 1 hour, the reaction mixture is filtered to afford the title compound as a beige solid; [M+H]+=266(268)

후처리

  1. filtrationthe reaction mixture is filtered

출처 및 근거

ORD 기록
ord-0ac4adbf422b4f86acf1b097b950f24c
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367662B2

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