참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 7-Azabicyclo(2.2.1)heptane | HCID 136093 | — |
| 반응물 | 2-Bromo-4-fluoro-1-nitrobenzene | HCID 2756993 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 7-(3-Bromo-4-nitrophenyl)-7-azabicyclo[2.2.1]heptane | HCID 57516846 | 255.1% |
반응 단계
To a solution of 2-bromo-4-fluoro-1-nitro-benzene (250 mg, 1.14 mmol) in DMSO (2 mL) was added 7-azabicyclo[2.2.1]heptane (182 mg, 1.36 mmol) portion-wise. The reaction was stirred at 80° C. for 24 h. The reaction was quenched with water and the aqueous layer was extracted with dichloromethane. The combined organic extracts were washed with 1 N HCl, dried over MgSO4, filtered and concentrated in vacuo to provide 7-(3-bromo-4-nitrophenyl)-7-azabicyclo[2.2.1]heptane (864 mg, 98% yield). LC/MS m/z 298.5 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08367660B2 |
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| 출처 데이터셋 | uspto-grants-2013_02 |
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| ORD ID | ord-df39a32b2f1d487dbab50ed4db68f71e |
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| 출처 메모 | uspto-grants-2013_02 |
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