참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Diethylamine, hydrochloride | HCID 12618 | — |
| 반응물 | Sodium sulfide monohydrate | HCID 19906495 | — |
| 반응물 | Ethyl[3-(3-cyano-6-oxo-6H-pyridazin-1-ylmethyl)phenyl]-carbamate | HCID 59406667 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Ethyl[3-(6-oxo-3-thiocarbamoyl-6h-pyridazin-1-yl-methyl)phenyl]carbamate | HCID 59406698 | — |
반응 단계
200 mg (0.67 mmol) of ethyl[3-(3-cyano-6-oxo-6H-pyridazin-1-ylmethyl)-phenyl]carbamate are dissolved in 1 ml of DMF, and 219 mg (2 mmol) of diethylammonium chloride and 165 mg (2 mmol) of sodium sulfide hydrate are added. The yellow suspension is stirred at 55° C. for 2 hours. 10 ml of water are added to the reaction mixture. The precipitate is filtered off with suction, washed with water and dried in vacuo. The substance is reacted further without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08367668B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_02 |
|---|
| ORD ID | ord-31010b8f76d946b3b04a246806827eee |
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| 출처 메모 | uspto-grants-2013_02 |
|---|
