Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 383827생성일: 2026년 10월 26일
Acetic Acid → 7-(4-(2-(4-Cyanopyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide
https://huagongshe.com/reaction/383827
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | 2-Vinylisonicotinonitrile | HCID 45080048 | — |
| 반응물 | N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide | HCID 59636743 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 7-(4-(2-(4-Cyanopyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide | HCID 66847540 | — |
반응 단계
The compound was prepared according to the procedure disclosed in Example 39 starting from of 2-vinylisonicotinonitrile (0.076 g, 0.59 mmol), N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide (0.080 g, 0.29 mmol) (Example 39d), and acetic acid (0.013 mL, 0.23 mmol). Ethanol was used as solvent and the reaction heated at 90° C. for two days. The crude product was purified by preparative HPLC to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08367676B2 |
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| 출처 데이터셋 | uspto-grants-2013_02 |
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| ORD ID | ord-51688835e6bf46c0b7feffc884d64030 |
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| 출처 메모 | uspto-grants-2013_02 |
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