Acetic Acid → Azetidin-1-yl(7-(piperazin-1-yl)benzofuran-2-yl)methanone

HRID 383834

반응식

HRID 383834 반응식
[N:1]1([C:5]([C:7]2[O:8][C:9]3[C:15]([N:16]4[CH2:21][CH2:20][N:19](CC5C=CC=CC=5)[CH2:18][CH2:17]4)=[CH:14][CH:13]=[CH:12][C:10]=3[CH:11]=2)=[O:6])[CH2:4][CH2:3][CH2:2]1.C(O)(=O)C.N>>[N:1]1([C:5]([C:7]2[O:8][C:9]3[C:15]([N:16]4[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]4)=[CH:14][CH:13]=[CH:12][C:10]=3[CH:11]=2)=[O:6])[CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 3

HCID 176Acetic AcidHCID 222AmmoniaHCID 59636710Azetidin-1-yl(7-(4-benzylpiperazin-1-yl)benzofuran-2-yl)methanone

생성물 1

HCID 59636763Azetidin-1-yl(7-(piperazin-1-yl)benzofuran-2-yl)methanone

실험 절차

The compound was prepared according to the procedure disclosed in Example 39d starting from azetidin-1-yl(7-(4-benzylpiperazin-1-yl)benzofuran-2-yl)methanone (0.52 g, 1.38 mmol) and acetic acid (0.63 mL, 11.1 mmol). A solution of ammonia (3 mL, 7N in MeOH) was added to the mixture after the reaction was complete. The solvent was removed by rotary evaporation. The crude product was purified by flash chromatography (SiO2; gradient 0-10% ammonia (7N in MeOH) in DCM). Yield: 0.36 g (91%).

후처리

  1. customThe compound was prepared
  2. customThe solvent was removed by rotary evaporation
  3. customThe crude product was purified by flash chromatography (SiO2; gradient 0-10% ammonia (7N in MeOH) in DCM)

출처 및 근거

ORD 기록
ord-97d8016b45934f8389c9ddd985f0c489
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367676B2

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