2-(5-Fluoropyridin-2-yl)ethyl 4-methylbenzenesulfonate → 7-(4-(2-(5-Fluoropyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide

HRID 383840

반응식

HRID 383840 반응식
[CH3:1][N:2]([CH3:20])[C:3]([C:5]1[O:6][C:7]2[C:13]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)=[CH:12][CH:11]=[CH:10][C:8]=2[CH:9]=1)=[O:4].CC1C=CC(S(O[CH2:32][CH2:33][C:34]2[CH:39]=[CH:38][C:37]([F:40])=[CH:36][N:35]=2)(=O)=O)=CC=1>>[F:40][C:37]1[CH:38]=[CH:39][C:34]([CH2:33][CH2:32][N:17]2[CH2:18][CH2:19][N:14]([C:13]3[C:7]4[O:6][C:5]([C:3]([N:2]([CH3:20])[CH3:1])=[O:4])=[CH:9][C:8]=4[CH:10]=[CH:11][CH:12]=3)[CH2:15][CH2:16]2)=[N:35][CH:36]=1

참가 물질

3

반응물 2

HCID 596367122-(5-Fluoropyridin-2-yl)ethyl 4-methylbenzenesulfonateHCID 59636743N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide

생성물 1

HCID 596367317-(4-(2-(5-Fluoropyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide

실험 절차

The compound was prepared according to the procedure disclosed in Example 46 starting from N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide (0.085 g, 0.31 mmol) (Example 39d) and 2-(5-fluoropyridin-2-yl)ethyl 4-methylbenzenesulfonate (0.092 g, 0.31 mmol). The product was purified by preparative HPLC to give the title compound. Yield: 0.049 g (39%).

후처리

  1. customThe compound was prepared
  2. customThe product was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-cb8e84e2a98748689f182a4ec8719589
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367676B2

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