참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 2-Amino-4-phenylpyrimidine | HCID 598777 | — |
| 반응물 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 반응물 | Methyl 3-bromo-4-methylbenzoate | HCID 7015747 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Methyl 4-methyl-3-(4-phenylpyrimidin-2-ylamino)benzoate | HCID 68466271 | 52.2% |
반응 단계
A mixture of 4-phenylpyrimidin-2-amine (100 mg, 0.58 mmol) and methyl 3-bromo-4-methylbenzoate (111 mg, 0.48 mmol), Cs2CO3 (221 mg, 0.68 mmol), Pd2(dba)3 (22 mg, 0.024 mmol) and Xantphos (22 mg, 0.039 mmol) in a microwave reaction vessel was suspended in 5 mL of toluene. The reaction mixture was heated in a microwave at 130° C. for 30 min, and then at 180° C. for 30 min. After cooling, the mixture was purified by ISCO system to give 80 mg of product (yield: 43%). MS (ESI+) m/z 320.1 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08367686B2 |
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| 출처 데이터셋 | uspto-grants-2013_02 |
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| ORD ID | ord-f292fd24b2054d5c854f4ca62260dc6d |
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| 출처 메모 | uspto-grants-2013_02 |
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