Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 4-Oxo-4-(3-(trifluoromethyl)benzylamino)butyric acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Succinic anhydride | HCID 7922 | — |
| 반응물 | 3-(Trifluoromethyl)benzylamine | HCID 75962 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 4-Oxo-4-(3-(trifluoromethyl)benzylamino)butyric acid | HCID 43397104 | 44.2% |
반응 단계
A solution of 15.0 g (85.6 mmol) of (3-(trifluoromethyl)phenyl)methylamine in ether (40 ml) was added dropwise to a suspension of 7.5 g (85.6 mmol) of succinic anhydride in ether (450 ml) within 30 min. The mixture was then stirred for 72 h at room temperature. The deposit obtained was filtered and dried. After column chromatography (EE/MeOH 1:1) of the residue, 10.4 g (37.8 mmol, 44%) of 4-oxo-4-(3-(trifluoromethyl)benzylamino)butyric acid were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08367700B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-c4e7352f5de849dca980d4cce877ddc6 |
| 출처 메모 | uspto-grants-2013_02 |