Methanol → HCID 178498115, 화합물

HRID 384100노트

반응식

HRID 384100 반응식
[OH:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH3:16]O>O>[OH:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH3:16])=[O:5]

참가 물질

5

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 178418543HCID 178418543, 화합물

생성물 1

HCID 178498115HCID 178498115, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 2-hydroxynicotinic acid (3.0 g) in methanol 15 ml, 1 ml of concentrated sulfuric acid was added, and the reaction solution was heated to reflux for 2 hours. The reaction solution was cooled, then the solvent was distilled off under reduced pressure, and the residue obtained was diluted with water and extracted with chloroform. The combined organic layers were washed with a saturated aqueous sodium bicarbonate solution and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to afford the title compound as a pale pink solid.

후처리

  1. temperaturethe reaction solution was heated
  2. temperatureto reflux for 2 hours
  3. temperatureThe reaction solution was cooled
  4. distillationthe solvent was distilled off under reduced pressure
  5. customthe residue obtained
  6. extractionextracted with chloroform
  7. washThe combined organic layers were washed with a saturated aqueous sodium bicarbonate solution
  8. dry with materialdried over anhydrous sodium sulfate
  9. distillationThe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-e58895fc25984385b6357a0fd5e599ec
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367708B2

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