Water → 3-Phenoxy-benzeneethanol

HRID 384130

반응식

HRID 384130 반응식
[O:1]([C:8]1[CH:9]=[C:10]([CH2:14][C:15](O)=[O:16])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O>O1CCCC1.B.O1CCCC1>[O:1]([C:8]1[CH:9]=[C:10]([CH2:14][CH2:15][OH:16])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 962WaterHCID 1417493-Phenoxyphenylacetic acid

생성물 1

HCID 139291293-Phenoxy-benzeneethanol

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 2723981Borane;tetrahydrofuran용매

실험 절차

To a solution of (3-phenoxyphenyl)acetic acid (1.157 g) in tetrahydrofuran (23 ml), 6.5 ml of borane-tetrahydrofuran complex (1.17M tetrahydrofuran solution) was added, and the reaction solution was stirred at room temperature for 2 hours. To the reaction solution was added water, and the mixture was extracted with chloroform and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue obtained was purified by silica gel column chromatography (eluent: ethyl acetate/hexane (10:90-80/20)) to afford the title compound as a colorless oil.

후처리

  1. extractionthe mixture was extracted with chloroform
  2. dry with materialdried over anhydrous sodium sulfate
  3. distillationThe solvent was distilled off under reduced pressure
  4. customthe residue obtained
  5. customwas purified by silica gel column chromatography (eluent: ethyl acetate/hexane (10:90-80/20))

출처 및 근거

ORD 기록
ord-41d8072ff54f4585ac33d72cb7cc8a8f
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367708B2

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