Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium hydroxide, monohydrate → 2-(Methylthio)-4-(1-phenylcyclopropylamino)pyrimidine-5-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium hydroxide, monohydrate | HCID 168937 | — |
| 반응물 | Ethyl 2-(methylthio)-4-(1-phenylcyclopropylamino)pyrimidine-5-carboxylate | HCID 58098733 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-(Methylthio)-4-(1-phenylcyclopropylamino)pyrimidine-5-carboxylic acid | HCID 58098787 | — |
반응 단계
To a solution of ethyl 2-(methylthio)-4-(1-phenylcyclopropylamino)pyrimidine-5-carboxylate (crude from step 2) in THF (4 mL) was added LiOH.H2O (150 mg, 3.57 mmol) in H2O (2 mL). The mixture was stirred at room temperature overnight. THF was removed under vacuum and the residue was acidified with 1N HCl, white solids precipitated out, which were collected by filtration, dried on vacuum to give 2-(methylthio)-4-(1-phenylcyclopropylamino) pyrimidine-5-carboxylic acid (646 mg). MS 302.3 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08367689B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-469f60f002e24906ace889bfbaca4df7 |
| 출처 메모 | uspto-grants-2013_02 |