Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → ethyl 2-chloro-4-((1-methyl-1H-pyrazol-4-yl)methylamino)pyrimidine-5-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Ethyl 2,4-dichloropyrimidine-5-carboxylate | HCID 104020 | — |
| 반응물 | (1-methyl-1H-pyrazol-4-yl)methanamine | HCID 671225 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | ethyl 2-chloro-4-((1-methyl-1H-pyrazol-4-yl)methylamino)pyrimidine-5-carboxylate | HCID 58098673 | — |
반응 단계
To a solution of ethyl 2,4-dichloropyrimidine-5-carboxylate (896 mg, 4 mmol) and (1-methyl-1H-pyrazol-4-yl)methanamine (445 mg, 4 mmol) in CH3CN (6 mL) at room temperature, DIEA (0.783 mL, 4.4 mmol) was added. The mixture was stirred at room temperature for 24 h, and was concentrated to give ethyl 2-chloro-4-((1-methyl-1H-pyrazol-4-yl)methylamino)pyrimidine-5-carboxylate as crude oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08367689B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-dccdebbb7ab3451aaf1cbe32fd927991 |
| 출처 메모 | uspto-grants-2013_02 |