Trifluoroacetic acid → HCID 42610782, 화합물

HRID 384646노트

반응식

HRID 384646 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]2[CH:21]=[C:20]([NH:22][C:23]3[CH:28]=[N:27][C:26]([C:29]#[N:30])=[CH:25][N:24]=3)[N:19]=[CH:18][N:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=[O:34]>>[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]2[N:17]=[CH:18][N:19]=[C:20]([NH:22][C:23]3[N:24]=[CH:25][C:26]([C:29]([NH2:30])=[O:34])=[N:27][CH:28]=3)[CH:21]=2)[CH2:10][CH2:9]1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 66746317Tert-butyl-4-((6-(5-cyanopyrazin-2-ylamino)pyrimidin-4-ylamino)methyl)-piperidine-1-carboxylate

생성물 1

HCID 42610782HCID 42610782, 화합물수율 15%

반응 조건

온도
82 °C

실험 절차

A mixture of tert-butyl-4-((6-(5-cyanopyrazin-2-ylamino)pyrimidin-4-ylamino)methyl)-piperidine-1-carboxylate (0.15 mmol) and trifluoroacetic acid was heated at 82° C. for 4 hours. The solution was evaporated to dryness and the residue was purified by preparative HPLC to give 5-(6-(piperidin-4-ylmethylamino)pyrimidin-4-ylamino)pyrazine-2-carboxamide (7.36 mg, 15%).

후처리

  1. customThe solution was evaporated to dryness
  2. customthe residue was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-29e210c2f0764a8496ab0843a399168d
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367658B2

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