Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → tert-Butyl 6-bromo-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | 5'-Bromo-2'-hydroxyacetophenone | HCID 95991 | — |
| 반응물 | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | tert-Butyl 6-bromo-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate | HCID 2794759 | — |
반응 단계
A mixture of 5-bromo-2-hydroxyacetophenone (104 g, 485 mmol), N-Boc-piperidin-4-one (98.6 g, 494 mmol), 20 mL of pyrrolidine (17.3 g, 243 mmol) and 261 mL of MeOH was heated under reflux until the reaction was complete. The mixture was cooled, then 87 mL of H2O were added, and the mixture was filtered and dried to give intended compound as a colorless solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524730B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-de58866a73cb48c7a016ae38f2f5ffeb |
| 출처 메모 | uspto-grants-2013_09 |