Tetrahydro-4H-pyran-4-ol → 5-Bromo-3-methyl-2-(oxan-4-yloxy)pyridine

반응식

[Br:1][C:2]1[CH:3]=[C:4]([CH3:9])[C:5]([OH:8])=[N:6][CH:7]=1.[O:10]1[CH2:15][CH2:14][CH:13](O)[CH2:12][CH2:11]1>>[Br:1][C:2]1[CH:3]=[C:4]([CH3:9])[C:5]([O:8][CH:13]2[CH2:14][CH2:15][O:10][CH2:11][CH2:12]2)=[N:6][CH:7]=1

참가 물질

반응물 2

HCID 74956Tetrahydro-4H-pyran-4-ol

HCID 178422464HCID 178422464, 화합물

생성물 1

HCID 684106265-Bromo-3-methyl-2-(oxan-4-yloxy)pyridine

실험 절차

The title compound was prepared from 5-bromo-2-hydroxy-3-methylpyridine and tetrahydro-4H-pyran-4-ol in analogy to Example 9c): colorless solid.

출처 및 근거

ORD 기록: ord-34ee81c0bb5a4a16b1732c3a1253f1be
출처 데이터셋: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08367838B2

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