Isopropanol → Rac-[1-(4-chloro-phenyl)-2-(4-isopropoxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

HRID 384907노트

반응식

HRID 384907 반응식
[C:1]([O:5][C:6](=[O:25])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1)=[O:10])([CH3:4])([CH3:3])[CH3:2].[CH:26](O)([CH3:28])[CH3:27]>>[C:1]([O:5][C:6](=[O:25])[NH:7][CH:8]([C:18]1[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH:26]([CH3:28])[CH3:27])=[CH:13][CH:12]=1)=[O:10])([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 3776IsopropanolHCID 68409176Rac-[1-(4-chloro-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

생성물 1

HCID 68408936Rac-[1-(4-chloro-phenyl)-2-(4-isopropoxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

실험 절차

The title compound was prepared from rac-[1-(4-chloro-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and isopropanol in analogy to Example 9c): MS (ISP): 404.4 (M+H)+.

출처 및 근거

ORD 기록
ord-594a3da269344c3fbd750182cc07ce2a
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367838B2

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