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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 384916생성일: 2026년 10월 26일

4-(4-Bromo-2,6-difluoro-phenoxy)-tetrahydro-pyran → Rac-[1-(3,4-dichloro-phenyl)-2-[3,5-difluoro-4-(tetrahydro-pyran-4-yloxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/384916

반응식

참여 물질

역할이름HCID투입량
반응물4-(4-Bromo-2,6-difluoro-phenoxy)-tetrahydro-pyranHCID 68409276—
반응물Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl esterHCID 87442373—
생성물Rac-[1-(3,4-dichloro-phenyl)-2-[3,5-difluoro-4-(tetrahydro-pyran-4-yloxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl esterHCID 68410060—

반응 단계

The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 4-(4-bromo-2,6-difluoro-phenoxy)-tetrahydro-pyran (Intermediate 18) in analogy to Example 1a): MS (ISP): 516.1 and 518.1 (M+H)+, 416.2 and 418.0 ((M-Boc)+H)+ (100%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08367838B2
출처 데이터셋uspto-grants-2013_02
ORD IDord-abe192268957436c848b09cf772c0fa4
출처 메모uspto-grants-2013_02