4-(4-Iodophenoxy)oxane → HCID 75228883, 화합물

HRID 384934노트

반응식

HRID 384934 반응식
C(OC(=O)[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9](=[O:14])N(OC)C)(C)(C)C.I[C:25]1[CH:37]=[CH:36][C:28]([O:29][CH:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)=[CH:27][CH:26]=1>>[NH2:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[CH:9]([C:25]1[CH:37]=[CH:36][C:28]([O:29][CH:30]2[CH2:31][CH2:32][O:33][CH2:34][CH2:35]2)=[CH:27][CH:26]=1)[OH:14]

참가 물질

3

반응물 2

HCID 242295244-(4-Iodophenoxy)oxaneHCID 87442373Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester2회

생성물 1

HCID 75228883HCID 75228883, 화합물

실험 절차

The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 4-(4-iodophenoxy)tetrahydropyran in analogy to Example 1a): MS (ISP): 480.2 and 482.1 (M+H)+, 424.1 and 426.0 ((M-isobutene)+H)+ (100%), 380.1 and 382.0 ((M-Boc)+H)+ (94%).

출처 및 근거

ORD 기록
ord-bd3d6f4845f14d8091a699a4c52423ec
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367838B2

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