1-Bromo-4-(2,2,2-trifluoroethoxy)benzene → Rac-[1-(3,4-dichloro-phenyl)-2-oxo-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-ethyl]-carbamic acid tert-butyl ester

HRID 384941

반응식

HRID 384941 반응식
[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9](=[O:14])N(OC)C)([CH3:4])([CH3:3])[CH3:2].Br[C:25]1[CH:30]=[CH:29][C:28]([O:31][CH2:32][C:33]([F:36])([F:35])[F:34])=[CH:27][CH:26]=1>>[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9](=[O:14])[C:25]1[CH:26]=[CH:27][C:28]([O:31][CH2:32][C:33]([F:34])([F:35])[F:36])=[CH:29][CH:30]=1)([CH3:2])([CH3:3])[CH3:4]

참가 물질

3

반응물 2

HCID 229138831-Bromo-4-(2,2,2-trifluoroethoxy)benzeneHCID 87442373Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester2회

생성물 1

HCID 68410008Rac-[1-(3,4-dichloro-phenyl)-2-oxo-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-ethyl]-carbamic acid tert-butyl ester

실험 절차

The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 1-bromo-4-(2,2,2-trifluoro-ethoxy)-benzene in analogy to Example 1a): MS (ISP): 478.1 and 480.1 (M+H)+, 378.2 and 380.0 ((M-Boc)+H)+ (100%).

출처 및 근거

ORD 기록
ord-b1df89d084304f269c5fab0e9f1d90f3
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367838B2

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