(3-Carbamoylphenyl)boronic acid → Rac-[2-(3'-carbamoyl-biphenyl-4-yl)-1-(3,4-dichloro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

HRID 384967노트

반응식

HRID 384967 반응식
[C:1]([O:5][C:6](=[O:26])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14](I)=[CH:13][CH:12]=1)=[O:10])([CH3:4])([CH3:3])[CH3:2].[NH2:27][C:28]([C:30]1[CH:31]=[C:32](B(O)O)[CH:33]=[CH:34][CH:35]=1)=[O:29]>>[C:1]([O:5][C:6](=[O:26])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14]([C:34]2[CH:33]=[CH:32][CH:31]=[C:30]([C:28](=[O:29])[NH2:27])[CH:35]=2)=[CH:13][CH:12]=1)=[O:10])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 2737814(3-Carbamoylphenyl)boronic acidHCID 68409915Rac-[1-(3,4-dichloro-phenyl)-2-(4-iodo-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

생성물 1

HCID 68409216Rac-[2-(3'-carbamoyl-biphenyl-4-yl)-1-(3,4-dichloro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

실험 절차

The title compound was prepared from rac-[1-(3,4-dichloro-phenyl)-2-(4-iodo-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and 3-aminocarbonylphenyl-boronic acid in analogy to Example 2b): MS (ISN): 497.2 and 499.2 (M−H)−.

출처 및 근거

ORD 기록
ord-7cf274cfa1814beab40f8ac483a23590
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367838B2

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