Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 384970생성일: 2026년 10월 26일
2-(3-Methoxy-allylidene)-malonic acid dimethyl ester → (R)-dimethyl 2-(3-(2,3-dihydro-1H-inden-1-ylamino)allylidene)malonate
https://huagongshe.com/reaction/384970
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-(3-Methoxy-allylidene)-malonic acid dimethyl ester | HCID 597992 | — |
| 반응물 | (R)-(-)-1-Aminoindan | HCID 2733933 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (R)-dimethyl 2-(3-(2,3-dihydro-1H-inden-1-ylamino)allylidene)malonate | HCID 86649726 | 97.4% |
반응 단계
A 500 ml round-bottom flask was charged with 5.0 g (1.0 eq.) (R)-2,3-dihydro-1H-inden-1-amine and 7.5 g (1.0 eq.) dimethyl 2-(3-methoxyallylidene)malonate in 120 ml dry THF. The mixture was heated at 65° C. under N2 for 3 hrs. Then the solvent was removed in vacuo, and the crude mixture was purified by silica gel flash column chromatography to afford (R)-dimethyl 2-(3-(2,3-dihydro-1H-inden-1-ylamino)allylidene)malonate as a yellow solid (11.0 g) in 97% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08367836B2 |
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| 출처 데이터셋 | uspto-grants-2013_02 |
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| ORD ID | ord-1d5205c8a5554bef9889ac4f906e5b8a |
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| 출처 메모 | uspto-grants-2013_02 |
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