Toluene → 3-t-Butyl-5-cyano-4-methoxybenzoyl chloride
반응식
[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([C:16]#[N:17])[C:13]=1[O:14][CH3:15])[C:8](O)=[O:9])([CH3:4])([CH3:3])[CH3:2].C1(C)C=CC=CC=1.S(Cl)([Cl:27])=O>CN(C)C=O>[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([C:16]#[N:17])[C:13]=1[O:14][CH3:15])[C:8]([Cl:27])=[O:9])([CH3:4])([CH3:3])[CH3:2]참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
To 3-t-butyl-5-cyano-4-methoxybenzoic acid (586 mg), toluene (10 mL), N,N-dimethylformamide (2 droplets) and thionyl chloride (0.27 mL) was added, and the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene to obtain the title compound (630 mg) as a brown oily substance.
후처리
- distillationThe solvent was distilled off under reduced pressure
- customazeotroped with toluene
출처 및 근거
- ORD 기록
- ord-ab39d87e500949cc8acb8858fd035b3d
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08367843B2
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