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Toluene → 3-Dimethylcarbamoyl-4-methoxy-5-trifluoromethylbenzoyl chloride

HRID 385110
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인쇄 미리보기

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HRID 385110 반응식
[CH3:1][N:2]([CH3:20])[C:3]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([C:16]([F:19])([F:18])[F:17])[C:13]=1[O:14][CH3:15])[C:8](O)=[O:9])=[O:4].C1(C)C=CC=CC=1.S(Cl)([Cl:30])=O>CN(C)C=O>[CH3:1][N:2]([CH3:20])[C:3]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([C:16]([F:19])([F:18])[F:17])[C:13]=1[O:14][CH3:15])[C:8]([Cl:30])=[O:9])=[O:4]
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참가 물질

5

반응물 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 68108962HCID 68108962, 화합물

생성물 1

HCID 866681743-Dimethylcarbamoyl-4-methoxy-5-trifluoromethylbenzoyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
60 °C

실험 절차

To 3-dimethylcarbamoyl-4-methoxy-5-trifluoromethylbenzoic acid (333 mg), toluene (3 mL), N,N-dimethylformamide (1 droplet) and thionyl chloride (0.13 mL) was added, and then the mixture was stirred at 60° C. for 6 hours. The solvent was distilled off under reduced pressure and the obtained residue was azeotroped with toluene and used for the synthesis of (f).

후처리

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe obtained residue was azeotroped with toluene
  3. customused for the synthesis of (f)

출처 및 근거

ORD 기록
ord-28fb25fc478a40868eeda7a53e8bf313
출처 데이터셋
uspto-grants-2013_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08367843B2

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