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Toluene → 4-Benzyloxy-3-trifluoromethylbenzoyl chloride

HRID 385115
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HRID 385115 반응식
[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][C:10]=1[C:18]([F:21])([F:20])[F:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(C)C=CC=CC=1.S(Cl)([Cl:31])=O>CN(C)C=O>[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([Cl:31])=[O:14])=[CH:11][C:10]=1[C:18]([F:21])([F:20])[F:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1
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참가 물질

5

반응물 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 167490234-(Benzyloxy)-3-(trifluoromethyl)benzoic acid

생성물 1

HCID 866681754-Benzyloxy-3-trifluoromethylbenzoyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
60 °C

실험 절차

To 4-benzyloxy-3-trifluoromethylbenzoic acid (444 mg), toluene (5 mL), N,N-dimethylformamide (2 droplets) and thionyl chloride (0.16 mL) were added, and then the mixture was stirred at 60° C. for 20 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene, and the obtained product was used for the synthesis of (h).

후처리

  1. distillationThe solvent was distilled off under reduced pressure
  2. customazeotroped with toluene
  3. customthe obtained product was used for the synthesis of (h)

출처 및 근거

ORD 기록
ord-f0f8665d587f4bf0a4796929d3797997
출처 데이터셋
uspto-grants-2013_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08367843B2

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