Iodine → Muconic Acid

HRID 385195

반응식

HRID 385195 반응식
[C:1]([OH:10])(=[O:9])/[CH:2]=[CH:3]\[CH:4]=[CH:5]\[C:6]([OH:8])=[O:7].II>C1COCC1>[C:1]([OH:10])(=[O:9])/[CH:2]=[CH:3]/[CH:4]=[CH:5]/[C:6]([OH:8])=[O:7]

참가 물질

4

반응물 2

HCID 807IodineHCID 5280614(2E,4Z)-2,4-Hexadienedioic acid

생성물 1

HCID 5356793Muconic Acid수율 84.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Cis,trans-muconic acid (19 g, 133.8 mmol) is dissolved in THF (250 mL) at room temperature and a crystal of iodine (160 mg, 0.63 mmol, 0.5 mole percent) is added. The reaction is performed in the presence of ambient light in the laboratory. The reaction mixture is allowed to stir at room temperature for 5 hours and the precipitant is filtered, washed with acetonitrile and dried under reduced pressure to yield 16 g of trans,trans-muconic acid, an 84 percent yield.

후처리

  1. filtrationthe precipitant is filtered
  2. washwashed with acetonitrile
  3. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-3c80a27d42cb4b9c98b18e73ef195655
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367858B2

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