Methyl Acrylate → Trimethyl cyclohexane-1,2,4-tricarboxylate

HRID 385223

반응식

HRID 385223 반응식
[C:1]([O:11][CH3:12])(=[O:10])/[CH:2]=[CH:3]/[CH:4]=[CH:5]/[C:6]([O:8][CH3:9])=[O:7].[C:13]([O:17][CH3:18])(=[O:16])C=C.[C:19](C1C=CC=C(O)C=1O)(C)(C)[CH3:20]>COCCOCCOC>[CH:5]1([C:6]([O:8][CH3:9])=[O:7])[CH2:20][CH2:19][CH:2]([C:1]([O:11][CH3:12])=[O:10])[CH2:3][CH:4]1[C:13]([O:17][CH3:18])=[O:16]

참가 물질

5

반응물 3

HCID 7294Methyl AcrylateHCID 77643tert-ButylcatecholHCID 5370244Dimethyl muconate, (E,E)-

생성물 1

HCID 12616206Trimethyl cyclohexane-1,2,4-tricarboxylate

시약·촉매·용매 1

HCID 8150Diglyme용매

반응 조건

온도
150 °C

실험 절차

In a 75 ml sealed tube, a stirred suspension of trans,trans dimethyl muconate (10.0 g, 58.8 mmol), two equivalents of methyl acrylate (10.6 ml, 117.6 mmol), neutral Al2O3 (300 mg of Aldrich 199974, 3 mass percent), and tert-butyl catechol (25 mg, 0.2 mol percent) in diglyme (20 ml, 2.9 M) is heated to 150° C. for 24 hours. After cooling to room temperature, the reaction mixture is filtered, transferred to a flask, and concentrated (0.5 M). Pd/C catalyst is added (856 mg (0.3 mol percent) of Johnson-Matthey 5 percent Pd/C #6) at room temperature. The flask is equipped with a reflux condenser, fritted gas dispersion tube, and internal T probe. Under N2 flow (190 ml/min) and stirring (190 rpm) the mixture is heated to reflux for 27 hours whereby trimethyl trimellitate (46 percent over 2 steps) is formed. Some trimethyl cyclohexane-1,2,4-tricarboxylate is also produced.

후처리

  1. customIn a 75 ml sealed tube
  2. temperatureAfter cooling to room temperature
  3. filtrationthe reaction mixture is filtered
  4. customtransferred to a flask
  5. concentrationconcentrated (0.5 M)
  6. additionPd/C catalyst is added (856 mg (0.3 mol percent) of Johnson-Matthey 5 percent Pd/C #6) at room temperature
  7. customThe flask is equipped with a reflux condenser, fritted gas dispersion tube
  8. temperatureis heated
  9. temperatureto reflux for 27 hours whereby trimethyl trimellitate (46 percent over 2 steps)
  10. customis formed

출처 및 근거

ORD 기록
ord-502af38940984e4d8975f9ccf5051f06
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367859B2

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