Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 38523생성일: 2026년 10월 24일
Hydrochloric Acid → Ethyl 4-[(3-chloro-4-fluorophenyl)amino]-5,7-dihydro-6H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidine-6-carboxylate
https://huagongshe.com/ko/reaction/38523
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 3-Chloro-4-fluoroaniline | HCID 9708 | — |
| 반응물 | Ethyl12-chloro-7-thia-4,9,11-triazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene-4-carboxylate | HCID 58116864 | — |
| 촉매 | 1,4-Dioxane | HCID 31275 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | Ethyl 4-[(3-chloro-4-fluorophenyl)amino]-5,7-dihydro-6H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidine-6-carboxylate | HCID 58116867 | 121.2% |
반응 단계
Ethyl 4-chloro-5,7-dihydro-6H-pyrrolo[3′,4′:4,5]thieno[2,3-d]pyrimidine-6-carboxylate from Example 21A (250 mg, 0.88 mmol) was dissolved in 2-propanol (2 mL). 3-Chloro-4-fluoroanilin (135 mg, 0.93 mmol) and a 4 M solution of gaseous hydrogen chloride in dioxane (11 μL, 0.04 mmol) were added, and the mixture was heated to 80° C. overnight. The precipitate was collected by suction filtration to yield 419 mg of the crude product (70% purity, 83% yield), which was used in the next step without purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08524722B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-36e09b5a15964098b25b59eac5145b24 |
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| 출처 메모 | uspto-grants-2013_09 |
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