Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzenamine, 3-ethynyl- → Ethyl 4-[(3-ethynylphenyl)amino]-5,7-dihydro-6H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidine-6-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| 반응물 | Ethyl12-chloro-7-thia-4,9,11-triazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene-4-carboxylate | HCID 58116864 | — |
| 생성물 | Ethyl 4-[(3-ethynylphenyl)amino]-5,7-dihydro-6H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidine-6-carboxylate | HCID 58116910 | — |
반응 단계
In analogy to Example 22A, ethyl 4-chloro-5,7-dihydro-6H-pyrrolo[3′,4′:4,5]thieno[2,3-d]pyrimidine-6-carboxylate from Example 21A (235 mg, 0.83 mmol) and 3-ethynylaniline (102 mg, 0.87 mmol) were reacted to the title compound to yield 211 mg (67%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524722B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-7d5a63bfe07342288577d481a66e9769 |
| 출처 메모 | uspto-grants-2013_09 |