Trifluoroacetic acid → Ethyl 3-hydroxy-4-oxopiperidine-1-carboxylate
반응식
[OH:1][CH:2]1[C:7](OC)([O:8]C)[CH2:6][CH2:5][N:4]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:3]1.FC(F)(F)C(O)=O>C1COCC1>[OH:1][CH:2]1[C:7](=[O:8])[CH2:6][CH2:5][N:4]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:3]1참가 물질
4
실험 절차
Ethyl 3-hydroxy-4,4-dimethoxypiperidine-1-carboxylate from Example 34A (5.00 g, 21.4 mmol) was dissolved in THF (50 mL), and trifluoroacetic acid (15.9 mL, 214 mmol) was added. The mixture was stirred for 3.5 h at rt. The solvent was then removed in vacuo. Twice, toluene was added and again removed in vacuo. The residue was dissolved in dichloromethane, dried over sodium sulfate, and the solvent was removed in vacuo to yield 4.70 g (95%) of an oil, which was used without further purification.
후처리
- customThe solvent was then removed in vacuo
- additionTwice, toluene was added
- customagain removed in vacuo
- dissolutionThe residue was dissolved in dichloromethane
- dry with materialdried over sodium sulfate
- customthe solvent was removed in vacuo
출처 및 근거
- ORD 기록
- ord-0f23eb935e624549bb2a1931a2483b84
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08524722B2
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