Benzenamine, 3-ethynyl- → Ethyl 4-[(3-ethynylphenyl)amino]-5,8-dihydropyrido[4',3':4,5]furo[2,3-d]pyrimidine-7(6H)-carboxylate
반응식
[C:1]([C:3]1[C:11]2[CH2:10][CH2:9][N:8]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:7][C:6]=2[O:5][C:4]=1/[N:17]=[CH:18]/[N:19](C)C)#[N:2].[C:22]([C:24]1[CH:25]=[C:26]([CH:28]=[CH:29][CH:30]=1)N)#[CH:23]>>[C:22]([C:24]1[CH:30]=[C:29]([NH:2][C:1]2[C:3]3[C:11]4[CH2:10][CH2:9][N:8]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:7][C:6]=4[O:5][C:4]=3[N:17]=[CH:18][N:19]=2)[CH:28]=[CH:26][CH:25]=1)#[CH:23]참가 물질
3
실험 절차
In analogy to Example 38A, the title compound was prepared from ethyl 3-cyano-2-{[(1E)(dimethylamino)methylidene]amino}-4,7-dihydrofuro[2,3-c]pyridine-6(5H)-carboxylate from Example 37A (1.20 g, 4.14 mmol) and 3-ethynylaniline (968 mg, 8.27 mmol) to yield 443 mg (28%).
후처리
- customto yield 443 mg (28%)