Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 5-nitro-1-(pyridin-2-ylmethyl)-1H-indazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Nitroindazole | HCID 21501 | — |
| 반응물 | Picolyl chloride hydrochloride | HCID 23392 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5-nitro-1-(pyridin-2-ylmethyl)-1H-indazole | HCID 22496149 | 50.5% |
반응 단계
5-Nitroindazole (10.0 g, 61.3 mmol) was dissolved in THF (100 mL), and 2-(chloromethyl)pyridine hydrochloride (8.60 g, 52.4 mmol) and potassium carbonate (24.4 g, 184 mmol) were added. The mixture was heated for 4 h to 75° C. Water was added, and the mixture was extracted with ethyl acetate. The organic layer was dried over sodium sulfate, and the solvent was removed in vacuo. The crude product was purified by column chromatography on silica gel (eluent: gradient cyclohexane/ethyl acetate 1:1 to ethyl acetate) to yield 6.73 g (43%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524722B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-91d9d9e2622743368ade6bd13677bb0a |
| 출처 메모 | uspto-grants-2013_09 |