Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-nitro-1-(pyridin-2-ylmethyl)-1H-indazole → 1-(Pyridin-2-ylmethyl)-1H-indazol-5-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-nitro-1-(pyridin-2-ylmethyl)-1H-indazole | HCID 22496149 | — |
| 촉매 | Adams' catalyst | HCID 345198 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-(Pyridin-2-ylmethyl)-1H-indazol-5-amine | HCID 21952366 | — |
반응 단계
A solution of the compound from Example 60A (6.73 g, 26.5 mmol) in ethanol (70 mL) was stirred with platinum dioxide (200 mg) under a hydrogen atmosphere at normal pressure for 3 h. The catalyst was removed by suction filtration, and the solvent was removed in vacuo. The residue was triturated with tert-butyl methyl ether, and the product was collected by suction filtration to yield 5.1 g (86%) as white crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524722B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-90eb0bc831d741f39e86405fc8981e47 |
| 출처 메모 | uspto-grants-2013_09 |