Potassium Hydroxide → Tert-butyl (3,4-dichloro-5-hydroxyphenyl)carbamate

HRID 38553노트

반응식

HRID 38553 반응식
[C:1]([O:5][C:6](=[O:17])[NH:7][C:8]1[CH:13]=[C:12](Cl)[C:11]([Cl:15])=[C:10]([Cl:16])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[OH-:18].[K+]>>[C:1]([O:5][C:6](=[O:17])[NH:7][C:8]1[CH:13]=[C:12]([OH:18])[C:11]([Cl:15])=[C:10]([Cl:16])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 14797Potassium HydroxideHCID 18929852N-(tert-Butoxycarbonyl)-3,4,5-trichloroaniline

생성물 1

HCID 58116863Tert-butyl (3,4-dichloro-5-hydroxyphenyl)carbamate

반응 조건

온도
90 °C

실험 절차

In analogy to Example 63A, tert-butyl(3,4,5-trichlorophenyl)carbamate from Example 66A (3.98 g, 13.4 mmol) was reacted with potassium hydroxide (1.77 g, 26.8 mmol). The reaction mixture was heated to 80° C. overnight and subsequently to 90° C. for 3 h. The product was isolated by preparative HPLC to yield 760 mg (20%).

후처리

  1. customThe product was isolated by preparative HPLC
  2. customto yield 760 mg (20%)

출처 및 근거

ORD 기록
ord-2834e6463a5c4394b92d7a553004b9d3
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524722B2

반응 노트

불러오는 중…