2-Fluorophenylboronic acid → Benzyl[3-(aminocarbonyl)-5-(2-fluorophenyl)-2-thienyl]carbamate

HRID 385697노트

반응식

HRID 385697 반응식
[CH2:1]([O:8][C:9](=[O:20])[NH:10][C:11]1[S:12][C:13](I)=[CH:14][C:15]=1[C:16]([NH2:18])=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1B(O)O>>[CH2:1]([O:8][C:9](=[O:20])[NH:10][C:11]1[S:12][C:13]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=2[F:21])=[CH:14][C:15]=1[C:16]([NH2:18])=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 27343542-Fluorophenylboronic acidHCID 59525870Benzyl[3-(aminocarbonyl)-5-iodo-2-thienyl]carbamate3회

생성물 1

HCID 59526021Benzyl[3-(aminocarbonyl)-5-(2-fluorophenyl)-2-thienyl]carbamate

실험 절차

The title compound was synthesized from benzyl[3-(aminocarbonyl)-5-iodo-2-thienyl]carbamate (Intermediate 1, Step 2) (300 mg, 0.746 mmol) and 2-fluorophenyl boronic acid (157 mg, 1.12 mmol) as the starting materials as described in Intermediate 1 Step 3.

출처 및 근거

ORD 기록
ord-5ad4fd2c9e0b4214a66f96e6c58b7cc7
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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