HCID 59525576, 화합물 → HCID 25123488, 화합물

HRID 385762노트

반응식

HRID 385762 반응식
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:23]1[N:28]=[C:27]([CH2:29][NH:30][CH:31]([CH3:36])[C:32]([CH3:35])([OH:34])[CH3:33])[CH:26]=[CH:25][CH:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[CH:24]=[CH:25][CH:26]=[C:27]([CH2:29][NH:30][CH:31]([CH3:36])[C:32]([OH:34])([CH3:33])[CH3:35])[N:28]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

참가 물질

3

반응물 2

HCID 59525576HCID 59525576, 화합물HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

생성물 1

HCID 25123488HCID 25123488, 화합물

실험 절차

The title compound was prepared by using the procedure listed in Example 1 with 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.080 g, 0.26 mmol) and 3-{[(6-bromopyridin-2-yl)methyl]amino}-2-methylbutan-2-ol (0.070 g, 0.26 mmol) as the starting materials.

출처 및 근거

ORD 기록
ord-cd0f4c04894d496a97a300348de03606
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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